10 Best Flea Treatments for Dogs in 2026, Recommended by Vets
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All products in this article have been reviewed by our trusted vets and experts. PetMD is owned by Chewy.
A flea and tick treatment for your dog is a must, as these year-round parasites are prevalent throughout the U.S., and with them can come discomfort, hair loss, scabs, anemia, and other issues caused by the diseases they can carry.
“Fleas and ticks carry diseases that are much easier to prevent than treat, especially ticks,” says Chewy veterinarian Stephanie Howe, DVM. “And many pets have allergies to fleas themselves. We can prevent a lot of discomfort by keeping up with prevention.”
Flea and tick treatments for dogs come in a variety of forms—from chews to topicals to collars. Some also target other types of parasites. The best flea and tick treatments for dogs are effective, easy to administer, formulated to protect against the specific parasites posing a threat to your pet, and backed by science and research studies.
To help you find the right option, our panel of veterinary experts rounded up their top choices for the best dog flea and tick treatments.
Flea and Tick Treatments for Dogs: What To Consider
When selecting the right flea and tick treatment for your dog, always consult your veterinarian and choose one that is not only easy to administer but also is appropriate for your pet’s age, weight, and coverage needs. Consider the following factors to help you narrow down the choices:
Prescription or OTC
Some flea treatments for dogs are readily available over the counter, while others are only available with a prescription from a veterinarian.
Veterinarians typically recommend prescription dog flea and tick medications, as these have undergone rigorous safety and clinical trials and are considered highly effective. Prescription medications may also prevent against other parasites, like mites and intestinal worms.
You can also find over-the-counter options that treat and prevent fleas and ticks without a prescription, often in tablet, collar, shampoo, or topical solution form.
Types of Parasites Treated
Speak with your veterinary team to determine which parasites pose a risk to your dog, based on their lifestyle, environment, and other factors.
There are several types of ticks that can be found throughout the U.S. and pose a threat to your dog. For example, the Lone Star tick, the primary cause of ehrlichiosis in dogs, is very common in the eastern, southeastern, and south-central United States.
Fleas and ticks aren’t the only parasites your dog needs protection from. Most veterinarians recommend flea and tick prevention for dogs that offer broad-spectrum coverage, offering protection against heartworms and/or intestinal worms like hookworms, roundworms, and tapeworms.
Your Dog’s Health, Age, and Weight
Flea and tick products are formulated for certain ages, weights, and health conditions, with some not appropriate for dogs under 8 weeks old, weighing under 4 pounds, or with a neurological disorder.
Form of Treatment
Flea and tick treatments come in a variety of forms: tablets, capsules, chews, collars, topical spot-ons, sprays, and shampoos. Choose one that’s easy for you to administer to your specific pet, as they are only effective if you follow the directions.
Efficacy
Depending on their ingredients, some flea and tick medications are more effective than others. Also, treatments can last anywhere from one day or so to several months.
Check the product packaging for length of effectiveness, and follow the dosing directions carefully to ensure full efficacy. Efficacy can change based on how often your pet goes swimming or how often they are bathed, so make sure you pick a product right for your pet’s lifestyle. Even the best flea and tick treatments for dogs only work when given on time, and when following the manufacturer’s directions on dosing.
Honorable Mentions
Though not included among our top winners, Advantage Multi, NexGard, and NexGard PLUS are also highly regarded by our veterinary expert panel for their proven protection.
Advantage Multi offers a broad-spectrum, topical formula applied monthly that protects against fleas, heartworms, roundworms, hookworms, whipworms, and mange. It is considered a potentially safer option for dogs with a history of seizures since it is not a member of the isoxazoline class. But all new medications for dogs with a history of seizures should be discussed with their veterinarian.
Beef-flavored NexGard Chewables are given monthly and are effective against fleas and ticks. NexGard PLUS, another convenient monthly, beef-flavored chew, provides comprehensive protection against fleas, ticks, heartworms, roundworms, and hookworms, making it another trusted option for pet parents who prefer oral preventives.
How We Chose the Best Flea and Tick Treatments for Dogs
This list of the best flea and tick treatments for dogs was meticulously curated by a panel of veterinarians and veterinary technicians who are employed by Chewy, the publisher of PetMD.
They were asked to choose the best flea and tick treatments for dogs in their professional opinion based on the following:
- Pests targeted
- Ease of application
- Effectiveness
- Safety
- Brand reputation
Opinions and product recommendations in this article belong solely to the review panel of veterinarians and animal health experts. Manufacturers and vendors cannot pay for placement in Vet Verified articles, or exert influence on our panelists as they evaluate products.
Our sole goal with this program is to provide you with the information you need to make the best decision for your pets.
Best Dog Flea and Tick Treatment FAQs
What is the most recommended flea and tick medicine for dogs?
Popular, vet-recommended flea and tick medicines for dogs include chewables Simparica and Credelio, plus Bravecto topical, all of which are prescription medicines. Your vet can help you choose the best flea and tick medication for your individual dog based on their specific needs.
What's the most effective flea treatment for dogs?
The most effective flea treatment for your particular pup will be suitable for their age and weight, fit their health and lifestyle needs, and will work against parasites found in the part of the country in which you live.
Today’s prescription flea medicines for dogs are not only fast acting, safe, and effective, but many are also effective on ticks and intestinal parasites.
What kills 100% of fleas?
Killing 100% of fleas requires a multi-prong approach. To completely get rid of a flea infestation you need to kill all stages of the flea’s life cycle, which includes the egg, larva, pupa, and adult stage. And to do that, you need to treat not only your pet but also the environment (home and yard), which is where non-adult fleas typically live.
Work with your veterinarian to select a flea treatment best suited for your dog, and use it consistently to eliminate all fleas. As for the home, vacuum regularly, wash pet bedding in hot water, and keep outdoor areas maintained. There are also sprays and other products available that treat furniture, carpet, and the yard.
What kills fleas on dogs the quickest?
Flea shampoos and sprays typically kill fleas on contact, and some oral pills, like Capstar, begin to kill fleas within 30 minutes. Though these types of products provide rapid relief, they should be paired with a long-term preventive to stop reinfestation. Be sure to talk to your vet first before combining any flea treatments for dogs.
